Asoformin; Avimet; Conformin; dibimet; formet ; Glumet ; Glyciphage
; Glycomet ; Insumet ; Medformin ; Metlife ; Obimet ; Omet ; Walaphage and
more……… most likely that you can
identify what this is easily as many Indians are buying this daily…….. One may not
easily identify ‘ATP/P2X7R pathway’ ~ sounds some computer
code… P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7
gene. The product of this gene belongs to the family of purinoceptors for ATP.
Multiple alternatively spliced variants which would encode different isoforms
have been identified although some fit nonsense-mediated decay criteria. The
receptor is found in the central and peripheral nervous systems, in microglia,
in macrophages, in uterine endometrium, and in the retina.
For
decades, patients have managed their type 1 diabetes by injecting themselves
with insulin to regulate the glucose in their blood. Initially it was painful ~
now there are fine needles available, still…….. it never is a happy state of
affairs…. They say Diabetes is not a disease but only a disorder – howsoever
you name it, one has to simply live with it… it is killing mentally ~ as you
cannot eat what you want to and would start feeling that the whole World exists
to eat ! and you are denied that pleasure.
Injecting insulin addresses the immediate danger of low insulin levels.
Diabetes
mellitus, or simply diabetes, is a group of metabolic diseases in which a
person has high blood sugar, either because the pancreas does not produce
enough insulin, or because cells do not respond to the insulin that is
produced. This high blood sugar produces
the classical symptoms of polyuria (frequent urination), polydipsia (increased
thirst) and polyphagia (increased hunger). There are three main types of
diabetes mellitus (DM). Type 1 DM results from the body's failure to produce
insulin, and currently requires the person to inject insulin or wear an insulin
pump. This form was previously referred to as "insulin-dependent diabetes
mellitus" (IDDM) or "juvenile diabetes". Type 2 DM results from
insulin resistance, a condition in which cells fail to use insulin properly,
sometimes combined with an absolute insulin deficiency. The third is
gestational diabetes occurring in pregnant women without a previous
diagnosis of diabetes develop a high blood glucose level. It may precede
development of type 2 DM.
Untreated,
diabetes can cause many complications. Acute complications include diabetic
ketoacidosis and nonketotic hyperosmolar coma. Serious long-term complications include
cardiovascular disease, chronic renal failure, and diabetic retinopathy
(retinal damage). Adequate treatment of diabetes is thus important, as well as
blood pressure control and lifestyle factors such as stopping smoking and
maintaining a healthy body weight.
Metformin
is an oral antidiabetic drug. It
reportedly is the first-line drug of choice for the treatment of type 2
diabetes. Metformin is an antidiabetic drug that has been conclusively
shown to prevent the cardiovascular complications of diabetes. When prescribed
appropriately, metformin causes few adverse effects (the most common is
gastrointestinal upset) and is associated with a low risk of hypoglycemia.
First synthesized and found to reduce blood sugar in the 1920s, metformin was
forgotten for the next two decades as research shifted to insulin and other
antidiabetic drugs. Interest in metformin was rekindled in the late 1940s after
several reports that it could reduce blood sugar levels in people; Metformin is
now believed to be the most widely prescribed antidiabetic drug in the world.
Now here is an article reproduced from - : bostonmagazine.com –
which sure would be music to ears of those
affected by Diabetes. The newsitem states that - Boston
Children’s Hospital has found the Root
Cause of Diabetes and that with just a little more study, they could possibly
cure type 1 diabetes. Treatment of diabetes without insulin shots – sounds too
good….
**** Boston Children’s Hospital
could be on the verge of curing type 1 diabetes. Seriously. This huge news,
which was announced today on their blog, could affect the 215,000 people in the
U.S. younger than 20 who have diabetes (type 1 or type 2). That’s a pretty huge
number, so it’s no wonder why it’s been called an epidemic.
People who live with type 1 diabetes have to inject themselves with
insulin to regulate the glucose in their blood. It’s an immediate fix, but
there are many long-term complications associated with diabetes, like heart and
kidney diseases, nerve problems, skin issues, and problems with vision, among
others. “Insulin injections can manage hyperglycemia by reducing the patient’s
glucose levels, but it is not the cure,” says Dr. Paolo Fiorina of the
Nephrology Division at Boston Children’s Hospital in the report. The Nephrology
Division was recently ranked number one in the country by U.S. News and World
Report.
Fiorina was looking for the molecular pathway that triggers
diabetes, hoping to find better treatment options with the ultimate goal of
finding a permanent cure. “In order to truly cure diabetes, we needed to
pinpoint exactly why this happens. And then prevent it,” Fiorina says.
According to Boston Children’s Hospital, Fiorina and his team found the root
cause of type 1 diabetes: Fiorina and his team studied hundreds of pathways in
animals with diabetes. They eventually isolated one, known as ATP/P2X7R, which
triggers the T-cell attacks on the pancreas, rendering it unable to produce
insulin.
“By identifying the ATP/P2X7R pathway as the early mechanism in the
body that fires up an alloimmune response, we found the root cause of
diabetes,” says Fiorina. “With the cause identified, we can now focus on
treatment options. Everything from drug therapies to transplants that require
less immunosuppression is being explored.”
It will still be a few years before they can test the therapies in
children, but the outcome of what was discovered here could be truly amazing.
“I believe it won’t be long before we can cure diabetes with a number of
different therapies depending on the needs of the patient,” Fiorina says on the
blog. “Then, if the right screening techniques for diabetes could be developed,
it would be entirely possible in many cases that we could prevent the disease
from ever developing in children. The future of diabetes treatment is very
exciting.”****
Great news indeed for the humanity…..
With
regards – S. Sampathkumar
17th
June 2013.
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